An IMP1 inhibitor (IC50 = 5 μM for IMP1 binding to c-Myc mRNA); downregulates c-Myc and β-TrCP1 mRNA and reduces IMP1 protein levels in SK-MEL-2 and IGROV-1 cells; inhibits proliferation of IMP1-positive ES-2

BTYNB IMP1 Inhibitor – 5 mg

Brand:
Cayman
CAS:
304456-62-0
Storage:
-20
UN-No:
Non-Hazardous - /

BTYNB IMP1 inhibitor is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA).{43310} It downregulates c-Myc and β-TrCP1 mRNA and reduces IMP1 protein levels in SK-MEL-2 and IGROV-1 cells. BTYNB IMP1 inhibits proliferation of IMP1-positive ES-2, IGROV-1, and SK-MEL-2 cells (IC50s = 2.3, 3.6, and 4.5 μM, respectively) but not IMP1-negative BG-1 and T47D-KBluc cells (IC50s = >50 μM for both). It also inhibits anchorage-independent growth of SK-MEL-2 cells when used at a concentration of 10 μM.  

 

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SKU: 25623 - 5 mg Category:

Description

An IMP1 inhibitor (IC50 = 5 μM for IMP1 binding to c-Myc mRNA); downregulates c-Myc and β-TrCP1 mRNA and reduces IMP1 protein levels in SK-MEL-2 and IGROV-1 cells; inhibits proliferation of IMP1-positive ES-2, IGROV-1, and SK-MEL-2 cells (IC50s = 2.3, 3.6, and 4.5 μM, respectively); inhibits anchorage-independent growth of SK-MEL-2 cells at 10 μM

Formal name: 2-[[(5-bromo-2-thienyl)methylene]amino]-benzamide

Synonyms: 

Molecular weight: 309.2

CAS: 304456-62-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals||Research Area|Cancer|Transcription Factors

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