A dual inhibitor of USP7 and USP47 (IC50s = 0.42 and 1 μM

USP7-USP47 Inhibitor – 1 mg

Brand:
Cayman
CAS:
1247825-37-1
Storage:
-20
UN-No:
Non-Hazardous - /

USP7-USP47 inhibitor is a dual inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 (IC50s = 0.42 and 1 μM, respectively).{24462} It is selective for USP7 and USP47 over USP2, USP5, USP8, USP21, USP28, caspase-3, and cathepsin B (IC50s = >31.6 μM). USP7-USP47 inhibitor inhibits the growth of HCT116 cells (EC50 = 7.6 μM).  

 

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SKU: 25622 - 1 mg Category:

Description

A dual inhibitor of USP7 and USP47 (IC50s = 0.42 and 1 μM, respectively); selective for USP7 and USP47 over USP2, USP5, USP8, USP21, USP28, caspase-3, and cathepsin B (IC50s = >31.6 μM); inhibits the growth of HCT116 cells (EC50 = 7.6 μM)

Formal name: 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-2-thiophenecarboxamide

Synonyms: 

Molecular weight: 484.4

CAS: 1247825-37-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer

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