A sphingolipid found in the stratum corneum of human skin; found in higher concentrations in female sebum compared to male sebum; levels positively correlate with cytotoxicity in CCRF-CEM

C24 dihydro Ceramide (d18:0/24:0) – 5 mg

Brand:
Cayman
CAS:
6063-36-1
Storage:
-20
UN-No:
Non-Hazardous - /

C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.{37371} It is found in higher concentrations in female sebum compared to male sebum.{43449} C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.{43450} Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squamous carcinoma cells in vitro. {43451} C24 dihydro Ceramide levels are also increased in INS-1 β-cells incubated with glucose and palmitate (Item No. 10010279).{43452}  

 

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Description

A sphingolipid found in the stratum corneum of human skin; found in higher concentrations in female sebum compared to male sebum; levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell ALL cell lines; levels increased by 149.49-fold in DEGS1 knockdown UM-SCC-22A human head and neck squamous carcinoma cells in vitro; levels are also increased in INS-1 β-cells incubated with glucose and palmitate

Formal name: N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-tetracosanamide

Synonyms:  Cer(d18:0/24:0)|N-Lignoceroyl-D-erythro-Sphinganine|N-Tetracosanoylsphinganine

Molecular weight: 652.1

CAS: 6063-36-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Cell Death||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Lipid Biochemistry|Sphingolipids

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