A naturally-occurring lysophospholipid; induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner

1-Oleoyl-2-hydroxy-sn-glycero-3-PE – 50 mg

Brand:
Cayman
CAS:
89576-29-4
Storage:
-20
UN-No:
Non-Hazardous - /

1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine.{36851,36852,36853} It induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner, an effect that can be blocked by the lysophosphatidic acid receptor 1 (LPA1) antagonist AM095 (Item No. 22141).{36852} 1-Oleoyl-2-hydroxy-sn-glycero-3-PE (100 ng/ml) increases IL-2 production in CD1d-stimulated murine natural killer T (NKT) cell hybridoma 2H4 cells.{36853} It also induces production of IL-4, but not IFN-γ, in murine splenocytes when used at a concentration of 100 ng/ml and in mouse serum when administered at a dose of 1 μg per animal, indicating induction of the T helper 2 (Th2) response. 1-Oleoyl-2-hydroxy-sn-glycero-3-PE levels increase in interscapular brown adipose tissue (iBAT) in mice following three-day cold exposure.{36851}  

 

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Description

A naturally-occurring lysophospholipid; induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner, an effect which can be blocked by the LPA1 antagonist AM095; increases IL-2 production in CD1d-stimulated murine NKT cell hybridoma 2H4 cells at 100 ng/ml; induces production of IL-4, but not IFN-γ, in murine splenocytes at 100 ng/ml and in mouse serum at 1 μg per animal; levels increase in iBAT in mice following three-day cold exposure

Formal name: 1-oleoyl-2-hydroxy-sn-glycero-3-phosphatidylethanolamine

Synonyms:  18:1 LPE|18:1 Lyso-PE|1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine

Molecular weight: 479.6

CAS: 89576-29-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Glycerophospholipids||Research Area|Endocrinology & Metabolism|Thermogenesis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Glycerophospholipids||Research Area|Neuroscience

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