Description
An inhibitor of MPS1/TTK (IC50 = 5.8 nM); inhibits MPS1 phosphorylation of KNL1 and increases the rate of mitosis at 100 nM; increases the number of missegregated chromosomes at 50 and 100 nM; inhibits colony formation of DLD1, HCT116, and U2OS cells (IC50s = 24.6, 20.1, and 20.6 nM, respectively)
Formal name: N-(2,6-diethylphenyl)-4,5-dihydro-8-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-1-methyl-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Synonyms:
Molecular weight: 580.7
CAS: 1202055-39-7
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins
