An oxysterol metabolite of cholesterol; inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors; binds to Nav channels and decreases action potentials in hippocampal neurons in vitro at 10 µM; increases survival of spinal cord motoneurons

5α,6β-Dihydroxycholestanol – 25 mg

Brand:
Cayman
CAS:
1253-84-5
Storage:
-20
UN-No:
Non-Hazardous - /

5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.{41987,41988} It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 µM.{41988} It increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro when used at concentrations ranging from 5 to 15 µM.{41989} 5α,6β-Dihydroxycholestanol is neuroprotective in a rat model of cerebral ischemia when administered at a dose of 12 mg/kg and increases latency to seizure onset and reduces severity of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in rats. 5α,6β-Dihydroxycholestanol has been used as a replacement for cholesterol in the study of cholesterol binding proteins.{41990}  

 

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Description

An oxysterol metabolite of cholesterol; inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors; binds to Nav channels and decreases action potentials in hippocampal neurons in vitro at 10 µM; increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro at 5-15 µM; neuroprotective in a rat model of cerebral ischemia at 12 mg/kg ; increases latency to seizure onset and reduces severity of PTZ-induced seizures in rats; has been used as a replacement for cholesterol in the study of cholesterol binding proteins

Formal name: cholestane-3β,5α,6β-triol

Synonyms:  5α,6β-di-OHC|Cholestanetriol|NSC 124751|NSC 18178

Molecular weight: 420.7

CAS: 1253-84-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Neuroscience|Seizure Disorders

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