An alkaloid with anti-inflammatory and antiproliferative properties; reduces production of NO

Mitraphylline – 5 mg

Brand:
Cayman
CAS:
509-80-8
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

Mitraphylline is the major pentacyclic oxindolic alkaloid found in U. tomentosa and has anti-inflammatory and antiproliferative properties.{37707,37708,37709,37710} It reduces production of nitric oxide (NO), IL-8, IL-6, and TNF-α as well as expression of inducible nitric oxide synthase (iNOS) in LPS-activated human neutrophils.{37707} Mitraphylline inhibits the growth of SKN-BE(2) neuroblastoma, GAMG glioblastoma, MHH-ES-1 Ewing’s sarcoma, and MT-3 breast cancer cells (IC50s = 12.3, 20, 17.15, and 11.18 μM, respectively).{37708,37709} In vivo, mitraphylline (30 mg/kg per day) inhibits LPS-induced release of IL-1α, IL-1β, IL-17, and TNF-α in mouse serum.{37710}  

 

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SKU: 25528 - 5 mg Category:

Description

An alkaloid with anti-inflammatory and antiproliferative properties; reduces production of NO, IL-8, IL-6, and TNF-α as well as expression of iNOS in LPS-activated human neutrophils; inhibits the growth of SKN-BE(2) neuroblastoma, GAMG glioblastoma, MHH-ES-1 Ewing’s sarcoma, and MT-3 breast cancer cells (IC50s = 12.3, 20, 17.15, and 11.18 μM, respectively); inhibits LPS-induced release of IL-1α, IL-1β, IL-17, and TNF-α in mouse serum at 30 mg/kg per day

Formal name: (1’S,3R,4’aS,5’aS,10’aR)-1,2,5′,5’a,7′,8′,10′,10’a-octahydro-1′-methyl-2-oxo-spiro[3H-indole-3,6′(4’aH)-[1H]pyrano[3,4-f]indolizine]-4′-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 368.4

CAS: 509-80-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity

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