A fungal metabolite with diverse biological activities; induces reducing sugar release in embryoless rice endosperms from 3-100 mg/L; enhances growth of rice seedlings (O. sativa) in combination with gibberellin A3 from 30-500 mg/L; reduces growth of C. albicans

Pestalotin – 500 µg

Brand:
Cayman
CAS:
34565-32-7
Storage:
-20
UN-No:
Non-Hazardous - /

Pestalotin is a fungal metabolite originally isolated from P. cryptomeriaecola with diverse biological activities.{37633} It induces reducing sugar release in embryoless rice endosperms when used at concentrations ranging from 3 to 100 mg/L and enhances growth of rice seedlings (O. sativa) when used in combination with gibberellin A3 at concentrations ranging from 30 to 500 mg/L. Pestalotin has antifungal activity, reducing the growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 12.5, 50, 50, and 50 μg/ml, respectively).{37634} It is cytotoxic to HL-60, MKN45, LoVo, and A549 cells (IC50s = 64.87-182.92 μM). Pestalotin has been used as a standard for dereplication of natural products.{41781}  

 

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Description

A fungal metabolite with diverse biological activities; induces reducing sugar release in embryoless rice endosperms from 3-100 mg/L; enhances growth of rice seedlings (O. sativa) in combination with gibberellin A3 from 30-500 mg/L; reduces growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 12.5, 50, 50, and 50 μg/ml, respectively); cytotoxic to HL-60, MKN45, LoVo, and A549 cells (IC50s = 64.87-182.92 μM); has been used as a standard for dereplication of natural products

Formal name: (6S)-5,6-dihydro-6-[(1S)-1-hydroxypentyl]-4-methoxy-2H-pyran-2-one

Synonyms:  (−)-Pestalotin

Molecular weight: 214.3

CAS: 34565-32-7

Purity: ≥99%

Formulation: A powder

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Plant Biology|Plant Growth Regulators

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