Description
A sulfonylurea and an inhibitor of pancreatic β-cell KATP channels (IC50 = 184 nM for murine β-cells); selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels (IC50s = 19.5 and 37.9 μM, respectively); increases insulin-induced glucose uptake and GLUT4 translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide at 5 μM; reduces LDL oxidation by HASMCs, decreasing TBARS content and 8-isoprostane levels at 5 and 10 μg/ml; decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion at 1-10 μg/ml; reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by STZ at 5mg/kg
Formal name: N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-benzenesulfonamide
Synonyms:
Molecular weight: 323.4
CAS: 21187-98-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation
