A fungal metabolite; 3-10-fold more cytotoxic to HeLa and L cells compared with (+)-rugulosin; protective against influenza in mice when administered via inhalation with a survival rate of 38.3%

(−)-Rugulosin – 5 mg

Brand:
Cayman
CAS:
21884-45-7
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-Rugulosin is a fungal metabolite that has been isolated from Penicillium species, including P. islandicum, which also produces the optical isomer and mycotoxin (+)-rugulosin (Item No. 23558).{37200} (–)-Rugulosin is 3-10-fold more cytotoxic to HeLa and L cells compared with (+)-rugulosin.{41880} It is protective against influenza in mice when administered via inhalation but not when administered intraperitoneally with 38.3 and 5% survival rates, respectively.{41881}  

 

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Description

A fungal metabolite; 3-10-fold more cytotoxic to HeLa and L cells compared with (+)-rugulosin; protective against influenza in mice when administered via inhalation with a survival rate of 38.3%

Formal name: [5aR-(5aR*,6S*,13aR*,14S*,17R*,18S*,19S*,20R*)]-1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-5H,6H-6,13a,5a,14-[1,2,3,4]butanetetraylcycloocta[1,2-b:5,6-b’]dinaphthalene-5,8,13,16(14H)-tetrone

Synonyms: 

Molecular weight: 542.5

CAS: 21884-45-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza

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