A cytotoxic indole alkaloid; cytotoxic to HepG2

(−)-Voacangarine – 5 mg

Brand:
Cayman
CAS:
545-84-6
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-Voacangarine is an indole alkaloid originally isolated from V. africana that is cytotoxic to HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 cells (IC50s = 20 µg/ml).{41812,41813} It is cytostatic to wild-type S. cerevisiae and cytotoxic to Δrad3-e5 and Δrad6-1 mutant S. cerevisiae, which are defective in DNA strand break repair and the mutagenic repair pathway, respectively.{41814}  

 

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SKU: 25468 - 5 mg Category:

Description

A cytotoxic indole alkaloid; cytotoxic to HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 cells (IC50s = 20 µg/ml); cytostatic to wild-type S. cerevisiae and cytotoxic to Δrad3-e5 and Δrad6-1 mutant S. cerevisiae

Formal name: 20S-hydroxy-12-methoxy-ibogamine-18-carboxylic acid, methyl ester

Synonyms:  (−)-Voacristine|NSC 306219

Molecular weight: 384.5

CAS: 545-84-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair

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