A phenylpropanoid hydroxycinnamic acid with diverse biological activities; inhibits collagen-induced human platelet aggregation (IC50 = 1.03 mM); scavenges DPPH and ABTS free radicals (IC50s = 8.3 and 5.4 μg/ml

Sinapic Acid – 5 g

Brand:
Cayman
CAS:
530-59-6
Storage:
-20
UN-No:
Non-Hazardous - /

Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities.{39903} Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM).{39905} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively.{30137} Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold.{39906} It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively).{39907} In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil (Item No. 14252) and bicuculline (Item No. 11727).{39903} Sinapic acid is also commonly used as a matrix in protein mass spectrometry.{39904}  

 

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Description

A phenylpropanoid hydroxycinnamic acid with diverse biological activities; inhibits collagen-induced human platelet aggregation (IC50 = 1.03 mM); scavenges DPPH and ABTS free radicals (IC50s = 8.3 and 5.4 μg/ml, respectively); reduces colony formation of SW480 human colon carcinoma cells by 4-fold at 200 μM; inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively); increases the time spent in the open arms of the elevated plus maze in mice at 4 mg/kg; commonly used as a matrix in protein mass spectrometry,

Formal name: 3-(4-hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid

Synonyms:  NSC 59261|Sinapinic Acid

Molecular weight: 224.2

CAS: 530-59-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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