Description
A macrolide antibiotic that is selective for S. aureus, MRSA, and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml); inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE at 0.00001-0.1 and 0.01-100 μg/mL, respectively; inhibits LPS-induced cytokine expression and nitric oxide production in murine BV-2 cells at 1 μM; reduces HL-60 cell proliferation increases cell differentiation when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid at 200 μM; reduces the number of CFUs in infected kidneys by 100,000-fold in a murine model of S. aureus infection at 50 mg/kg, p.o
Formal name: 1H-pyrrole-2-carboxylic acid, (1E,3R,4S,7S,8aS,10aR,11R,12R,13R,14R,14aS,14bS)-3,4,6,7,8,8a,10a,11,12,13,14,14a-dodecahydro-14-hydroxy-4-[(1R)-1-hydroxyethyl]-7-methoxy-1,3,13-trimethyl-6-oxo-11,14b-epoxy-14bH-naphth[2,1-e]oxecin-12-yl ester
Synonyms: Antibiotic 47444|CP 47,444|NSC 355066
Molecular weight: 515.6
CAS: 70695-02-2
Purity: ≥99%
Formulation: A solid
Product Type|Biochemicals|Antibiotics|Macrolides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases
