An internal standard for the quantification of curcumin by GC- or LC-MS

Curcumin-d6 – 5 mg

Brand:
Cayman
CAS:
1335198-02-1
Storage:
-20
UN-No:
Non-Hazardous - /

Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin (Item Nos. 81025 | 81025.1) by GC- or LC-MS. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities.{1421,42430,1420,1419} It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells.{1421} Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells.{42430} In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse skin.{1420} Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.{1419}  

 

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Description

An internal standard for the quantification of curcumin by GC- or LC-MS,

Formal name: (1E,4Z,6E)-5-hydroxy-1,7-bis[4-hydroxy-3-(methoxy-d3)phenyl]-1,4,6-heptatrien-3-one

Synonyms: 

Molecular weight: 374.4

CAS: 1335198-02-1

Purity: ≥99% deuterated forms (d1-d6)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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