An internal standard for the quantification of candesartan by GC- or LC-MS

Candesartan-d4 – 1 mg

Brand:
Cayman
CAS:
1346604-70-3
Storage:
-20
UN-No:
Non-Hazardous - /

Candesartan-d4 is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an inhibitor of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for human AT1, rat AT1A, and rat AT1B recombinant receptors, respectively).{28032} It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the human recombinant AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg).{42295} Candesartan is a metabolite of the orally bioavailable prodrug candesartan cilexetil (Item No. 10489). Formulations containing candesartan have been used in the treatment of hypertension and heart failure.  

 

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SKU: 25419 - 1 mg Category:

Description

An internal standard for the quantification of candesartan by GC- or LC-MS

Formal name: 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl-2,3,5,6-d4]methyl]-1H-benzimidazole-7-carboxylic acid

Synonyms: 

Molecular weight: 444.5

CAS: 1346604-70-3

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation

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