An ATM kinase inhibitor; inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of ATM targets in HeLa cells at 10 μM; selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts

CP 466,722 – 25 mg

Brand:
Cayman
CAS:
1080622-86-1
Storage:
-20
UN-No:
Non-Hazardous - /

CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM.{36744} It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).{36744}  

 

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Description

An ATM kinase inhibitor; inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of ATM targets in HeLa cells at 10 μM; selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively; decreases cell survival in response to ionizing radiation in HeLa cells; cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively)

Formal name: 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine

Synonyms: 

Molecular weight: 349.4

CAS: 1080622-86-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|ATM||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ATM Signaling||Research Area|Cancer|DNA Damage and Repair

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