A prodrug form of itaconate; hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages; increases Nrf2 protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages; decreases serum levels of IL-1β and TNF-α

4-octyl Itaconate – 250 mg

Brand:
Cayman
CAS:
3133-16-2
Storage:
-20
UN-No:
Non-Hazardous - /

4-octyl Itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1.{42667,40962} It is hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages where it acts as a regulator of macrophage function with anti-inflammatory properties.{40962} 4-octyl Itaconate increases nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages. In vivo, 4-octyl itaconate (50 mg/kg) decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice.  

 

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SKU: 25374 - 250 mg Category:

Description

A prodrug form of itaconate; hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages; increases Nrf2 protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages; decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice at 50 mg/kg,

Formal name: 2-methylene-butanedioic acid, 4-octyl ester

Synonyms: 

Molecular weight: 242.3

CAS: 3133-16-2

Purity: ≥98% (mixture of tautomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Immunology & Inflammation|Innate Immunity

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