An internal standard for the quantification of artemisinin by GC- or LC-MS

Artemisinin-d3 – 1 mg

Brand:
Cayman
CAS:
176652-07-6
Storage:
-20
UN-No:
Non-Hazardous - /

Artemisinin-d3 is intended for use as an internal standard for the quantification of artemisinin (Item No. 11816). Artemisinin is an endoperoxide antimalarial agent with anticancer activity.{21232,37702} It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg.{21232,37703} It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day).{37704} Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner.{37702} It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.  

 

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SKU: 25359 - 1 mg Category:

Description

An internal standard for the quantification of artemisinin by GC- or LC-MS

Formal name: [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-octahydro-3,6-dimethyl-9-(methyl-d3)-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one

Synonyms: 

Molecular weight: 285.4

CAS: 176652-07-6

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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