A non-selective β-AR and 5-HT receptor antagonist; binds to human β1-

Alprenolol – 100 mg

Brand:
Cayman
CAS:
13655-52-2
Storage:
-20
UN-No:
Non-Hazardous - /

Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.{25151,41186} It binds to β1-, β2-, and β3-ARs expressed in CHO cells (Kds = 15, 0.91, and 117 nM, respectively, for the human receptors) and to 5-HT1A and 5-HT1B receptors in rat hippocampal and striatal membranes (Kis = 34 and 134 nM, respectively).{25151,41186} In vivo, alprenolol (40 mg/kg, i.v.) completely blocks the hyperactivity response of rats to 2-PCPA (Item No. 10010494) and L-tryptophan.{25891} Alprenolol (10 μg, i.v.) inhibits decreases in heart rate and left ventricular systolic pressure induced by the β2-AR antagonist ICI 118551 (Item No. 15591) in transgenic mice overexpressing the β2-AR.{36710} It also reduces the level of abnormal prion fibrils (PrPSc) in the brain of mice intracerebrally infected with prion disease to less than 20% of control levels when administered in drinking water at a dose of 50 mg/L.{36711}  

 

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SKU: 25338 - 100 mg Category:

Description

A non-selective β-AR and 5-HT receptor antagonist; binds to human β1-, β2-, and β3-ARs (Kds = 15, 0.91, and 117 nM, respectively); binds to 5-1A and 5-HT1B in rat hippocampal and striatal membranes (Kis = 34 and 134 nM, respectively); completely blocks the hyperactivity response of rats to 2-PCPA and L-tryptophan at 40 mg/kg, i.v.; inhibits decreases in heart rate and left ventricular systolic pressure induced by ICI 118551 at 10 μg, i.v; reduces abnormal PrPSc levels in the brain of intracerebrally prion-infected mice to less than 20% of control at 50 mg/L, p.o.,

Formal name: 1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yl)phenoxy]-2-propanol

Synonyms:  (±)-Alprenolol|(RS)-Alprenolol|dl-Alprenolol

Molecular weight: 249.4

CAS: 13655-52-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neurodegenerative Disorders|Prion Disease

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