A catecholaminergic neurotoxin; has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents; induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra

6-OHDA (hydrobromide) – 250 mg

Brand:
Cayman
CAS:
636-00-0
Storage:
-20
UN-No:
Non-Hazardous - /

6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson’s disease in rodents.{37722} It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.{37727} Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.{37726} It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.{37723,37724} 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.{37724,37725}  

 

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Description

A catecholaminergic neurotoxin; has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson’s disease in rodents; induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, MFB, or striatum at doses of 9, 6, and 18 μg, respectively; decreases dopamine and norepinephrine levels in rat brain at 200 μg; induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells at 50 μM; activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular ROS in PC12 cells at 75 μM; induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB

Formal name: 5-(2-aminoethyl)-1,2,4-benzenetriol, monohydrobromide

Synonyms:  2,4,5-Trihydroxyphenethylamine|6-hydroxy Dopamine|Oxidopamine

Molecular weight: 250.1

CAS: 636-00-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Toxins||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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