A sulfatide lacking the fatty acyl group; decreases migration and adhesion of B35 neuroblastoma cells at 20 µM; inhibits PKC and cytochrome c at 150 and 50-100 µM

3’-sulfo Galactosylsphingosine (ammonium salt) – 1 mg

Brand:
Cayman
CAS:
1246681-32-2
Storage:
-20
UN-No:
Non-Hazardous - /

3’-sulfo Galactosylsphingosine is a form of sulfatide (Item No. 24323) that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 µM.{43066} It also inhibits PKC and cytochrome c oxidase activity when used at concentrations of 150 and 50-100 µM, respectively.{43067} 3’-sulfo Galactosylsphingosine accumulates in patients with metachromatic leukodystrophy, a lysosomal storage disorder characterized by arylsulfatase A (ASA) deficiency leading to progressive demyelination and neuromotor deficits.{43068} In mice lacking ASA, levels of 3’-sulfo galactosylsphingosine increase after one month of age followed by demyelination and neuromotor deficits.{43067,43068} 3’-sulfo Galactosylsphingosine has been used as a standard for the quantification of 3’-sulfo galactosylsphingosine by LC-MS.{38965} [Matreya, LLC. Catalog No. 1904]  

 

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SKU: 25316 - 1 mg Category:

Description

A sulfatide lacking the fatty acyl group; decreases migration and adhesion of B35 neuroblastoma cells at 20 µM; inhibits PKC and cytochrome c at 150 and 50-100 µM, respectively; levels increase in ASA-deficient mice; has been used as a standard for the quantification of sulfatides by LC-MS

Formal name: (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl, β-D-galactopyranoside, 3-(hydrogen sulfate), monoammonium salt

Synonyms:  Lyso 3’-sulfo Galactosylceramide|Lyso-Sulfatide|Sphingosine-1-Galactoside-3-Sulfate|Sulfogalactosylsphingosine

Molecular weight: 558.7

CAS: 1246681-32-2

Purity: ≥98%

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Neurodegenerative Disorders

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