An internal standard for the quantification of propranolol by GC- or LC-MS

(±)-Propranolol-d7 – 500 µg

Brand:
Cayman
CAS:
344298-99-3
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-Propranolol-d7 is intended for use as an internal standard for the quantification of propranolol (Item Nos. 23349 | 17291) by GC- or LC-MS. (±)-Propranolol is a β-adrenergic receptor (β-AR) antagonist (Kds = 6.91, 0.832, and 117.49 nM for human β1-, β2-, and β3-ARs, respectively).{25151} It reduces mean blood pressure, resting heart rate, and contractility and increases AV conduction time in dogs.{30090} (±)-Propranolol restores normal sinus rhythm in dogs with ouabain-induced arrhythmias (ED50 = 3.8 mg/kg).{39376} It also acts as a non-specific serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats.{25891} Formulations containing (±)-propranolol have been used for the treatment of hypertension, angina pectoris, and cardiac ischemia.  

 

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SKU: 25282 - 500 µg Category:

Description

An internal standard for the quantification of propranolol by GC- or LC-MS

Formal name: 1-[(1-methylethyl)amino]-3-(1-naphthalenyl-2,3,4,5,6,7,8-d7-oxy)-2-propanol

Synonyms: 

Molecular weight: 266.4

CAS: 344298-99-3

Purity: ≥99% deuterated forms (d1-d7)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Arrhythmia

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