An internal standard for the quantification of colchicine by GC- or LC-MS

Colchicine-d6 – 1 mg

Brand:
Cayman
CAS:
1217651-73-4
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

Colchicine-d6 is intended for use as an internal standard for the quantification of colchicine (Item No. 9000760) by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.{14772} It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM.{14772} Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.{19463,19464}  

 

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SKU: 25280 - 1 mg Category:

Description

An internal standard for the quantification of colchicine by GC- or LC-MS

Formal name: (S)-N-(1,2,3-trimethoxy-10-(methoxy-d3)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide-2,2,2-d3

Synonyms: 

Molecular weight: 405.5

CAS: 1217651-73-4

Purity: ≥99% deuterated forms (d1-d6)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Innate Immunity

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