An internal standard for the quantification of aprepitant by GC- or LC-MS

Aprepitant-d4 – 500 µg

Brand:
Cayman
CAS:
1133387-60-6
Storage:
-20
UN-No:
Non-Hazardous - /

Aprepitant-d4 is intended for use as an internal standard for the quantification of aprepitant (Item No. 14867) by GC- or LC-MS. Aprepitant an antiemetic compound and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM; IC50 = 0.09 nM for the human receptor).{24162,24160} It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3).{24162} In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P (Item No. 24035).{24161} It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting.  

 

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SKU: 25232 - 500 µg Category:

Description

An internal standard for the quantification of aprepitant by GC- or LC-MS

Formal name: 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl-2,3,5,6-d4)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Synonyms: 

Molecular weight: 538.5

CAS: 1133387-60-6

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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