An internal standard for the quantification of duloxetine by GC- or LC-MS

Duloxetine-d3 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1188266-11-6
Storage:
4
UN-No:
Non-Hazardous - /

Duloxetine-d3 is intended for use as an internal standard for the quantification of duloxetine (Item No. 14317) by GC- or LC-MS. (S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes).{25641} It also inhibits dopamine reuptake (Ki = 369 nM). (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively).{25642} It also decreases immobility time and increases latency to first immobility in the forced swim test in mice when administered at doses of 16 and 32 mg/kg.{41773} Formulations containing (S)-duloxetine have been used in the treatment of major depressive disorder, generalized anxiety disorder, chronic neuropathic and musculoskeletal pain, and fibromyalgia.  

 

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SKU: 25229 - 1 mg Category:

Description

An internal standard for the quantification of duloxetine by GC- or LC-MS

Formal name: N-(methyl-d3)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine, monohydrochloride

Synonyms:  LY248686-d3

Molecular weight: 336.9

CAS: 1188266-11-6

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Pain Research

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