A cardiac glycoside with anticancer activity; increases viability and proliferation of CMECs at 2-50 µM; improves left ventricular structure and function in a rat model of chronic heart failure; inhibits cell proliferation in nine lung cancer cell lines (IC50s = 0.12-53 µM); induces apoptosis in SGC-7901 and MGC-803 gastric cancer cells and activates the ERK1/2-EGR1 pathway; reduces tumor growth in an HCC mouse xenograft model at 5 and 20 mg/kg; inhibits tumor growth in an A549 lung cancer mouse xenograft model at 50 and 100 µg

Periplocin – 1 mg

Brand:
Cayman
CAS:
13137-64-9
Storage:
-20
UN-No:
- 2811 / 6.1

Periplocin is a cardiac glycoside that has been isolated from P. sepium and has cardiac and anticancer activity.{37618} It increases viability and proliferation of mouse cardiac microvascular endothelial cells (CMECs) when used at concentrations ranging from 2 to 50 µM and improves left ventricular structure and function in a rat model of chronic heart failure.{37621,37622} Periplocin inhibits cell proliferation in nine lung cancer cell lines in a time- and dose-dependent manner with IC50 values ranging from 0.12 to 53 µM.{37619} It induces apoptosis in SGC-7901 and MGC-803 gastric cancer cells and activates the ERK1/2-EGR1 pathway.{37620} Periplocin (5 and 20 mg/kg) reduces tumor growth in a hepatocellular carcinoma (HCC) mouse xenograft model.{37618} It also inhibits AKT and ERK autophosphorylation and tumor growth in an A549 lung cancer mouse xenograft model when administered at doses of 50 and 100 µg.{37619}  

 

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SKU: 25216 - 1 mg Category:

Description

A cardiac glycoside with anticancer activity; increases viability and proliferation of CMECs at 2-50 µM; improves left ventricular structure and function in a rat model of chronic heart failure; inhibits cell proliferation in nine lung cancer cell lines (IC50s = 0.12-53 µM); induces apoptosis in SGC-7901 and MGC-803 gastric cancer cells and activates the ERK1/2-EGR1 pathway; reduces tumor growth in an HCC mouse xenograft model at 5 and 20 mg/kg; inhibits tumor growth in an A549 lung cancer mouse xenograft model at 50 and 100 µg

Formal name: (3β,5β)-3-[(2,6-dideoxy-4-O-β-D-glucopyranosyl-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-card-20(22)-enolide

Synonyms: 

Molecular weight: 696.8

CAS: 13137-64-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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