A phytochemical with diverse biological activities; reduces the growth of B16/F10 murine melanoma cells from 40 to 100 μM; reduces tumor growth in a B16/F10 mouse xenograft model at 10 mg/kg; inhibits RANKL-induced osteoclast differentiation and decreases fusion and migrations of pre-osteoclasts in vitro and prevents LPS-induced bone erosion in mice; increases latency to the first EEG discharge and attenuates the intensity and reduces the frequency of seizure discharges in the parietal cortex in a mouse model of kainic acid-induced seizures at 20 mg/kg; reduces retinal expression of VEGR2 and neovascularization in rats with streptozotocin-induced diabetes; reduces hepatic collagen expression

Decursin – 10 mg

Brand:
Cayman
CAS:
5928-25-6
Storage:
-20
UN-No:
Non-Hazardous - /

Decursin is a phytochemical originally isolated from A. gigas with diverse biological activities.{39913,39914,39915,39916,39917} It reduces the growth of B16/F10 murine melanoma cells, but not NIH-3T3 fibroblasts, via induction of apoptosis and increased caspase-3 activity when used at concentrations ranging from 40 to 100 μM.{39913} In vivo, decursin (10 mg/kg, i.p.) reduces tumor growth in a B16/F10 mouse xenograft model. Decursin inhibits RANKL-induced osteoclast differentiation and decreases fusion and migrations of pre-osteoclasts in vitro and prevents LPS-induced bone erosion in mice.{39914} In a mouse model of seizures induced by kainic acid (Item No. 78050), decursin (20 mg/kg) increases latency to the first electroencephalographic (EEG) discharge and attenuates the intensity and reduces the frequency of seizure discharges in the parietal cortex.{39915} Decursin inhibits tube formation and expression of VEGF receptor 2 (VEGFR2) in human retinal microvascular endothelial cells (HRMECs) and human umbilical vein endothelial cells (HUVECs) in vitro and reduces retinal expression of VEGFR2 and neovascularization in rats with diabetes induced by streptozotocin (Item No. 13104).{39916} It also reduces hepatic collagen expression, serum levels of ALT, AST, and ALP, and production of reactive oxygen species (ROS) in a mouse model of CCL4-induced liver fibrosis.{39917}  

 

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Description

A phytochemical with diverse biological activities; reduces the growth of B16/F10 murine melanoma cells from 40 to 100 μM; reduces tumor growth in a B16/F10 mouse xenograft model at 10 mg/kg; inhibits RANKL-induced osteoclast differentiation and decreases fusion and migrations of pre-osteoclasts in vitro and prevents LPS-induced bone erosion in mice; increases latency to the first EEG discharge and attenuates the intensity and reduces the frequency of seizure discharges in the parietal cortex in a mouse model of kainic acid-induced seizures at 20 mg/kg; reduces retinal expression of VEGR2 and neovascularization in rats with streptozotocin-induced diabetes; reduces hepatic collagen expression, serum levels of ALT, AST, and ALP, and production of ROS in a mouse model of CCL4-induced liver fibrosis,

Formal name: 3-methyl-2-butenoic acid, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester

Synonyms:  (+)-Decursin

Molecular weight: 328.4

CAS: 5928-25-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Neuroscience|Seizure Disorders

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