A pyranocoumarin with diverse biological activities; inhibits the growth of various cancer cell lines (ED50s = 24-56 μM); decreases estrogen-stimulated growth of MCF-7 breast cancer cells; activates PKC purified from rat brain; selectively inhibits CYP1A1/2 over CYP2D15 and CYP3A12 in canine liver microsomes (Kis = 67.56

Decursinol angelate – 5 mg

Brand:
Cayman
CAS:
130848-06-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A. gigas and has diverse biological activities.{42374,42375,42376,42377,42378} It inhibits the growth of K562, HL-60, KG-1, SK-BR-3, AGS, A549, HeLa, HepG2, and G-361 cancer cells (ED50s = 24-56 μM) and decreases estrogen-stimulated growth of MCF-7 breast cancer cells in a concentration-dependent manner via decreased estrogen receptor α (ERα) protein levels and signaling activity.{42374,42375} Decursinol angelate (30 μM) activates PKC purified from rat brain.{42374} It selectively inhibits the cytochrome P450 (CYP) isoform CYP1A1/2 over CYP2D15 and CYP3A12 in canine liver microsomes (Kis = 67.56, 872.5, and 853.9 μM, respectively).{42376} Decursinol angelate (0.01-10 μM) reduces cytotoxicity and malondialdehyde (MDA) production induced by amyloid-β (23-35) (Aβ25-35) and increases superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in PC12 cells.{42377} In mice, decursinol angelate (200 mg/kg) has antinociceptive activity in the tail flick and hot plate tests and reduces acetic acid-induced writhing as well as decreases production of the pro-inflammatory cytokines TNF-α and IL-1β.{42378}  

 

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SKU: 25212 - 5 mg Category:

Description

A pyranocoumarin with diverse biological activities; inhibits the growth of various cancer cell lines (ED50s = 24-56 μM); decreases estrogen-stimulated growth of MCF-7 breast cancer cells; activates PKC purified from rat brain; selectively inhibits CYP1A1/2 over CYP2D15 and CYP3A12 in canine liver microsomes (Kis = 67.56, 872.5, and 853.9 μM, respectively); reduces Aβ25-35-induced cytotoxicity and MDA production and increases SOD and GPx activities in PC12 cells; has antinociceptive activity in the tail flick and hot plate tests and reduces acetic acid-induced writhing in mice at 200 mg/kg ,

Formal name: (2Z)-2-methyl-2-butenoic acid, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b’]dipyran-7-yl ester

Synonyms: 

Molecular weight: 328.4

CAS: 130848-06-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Small Molecule Activators|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Pain Research||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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