A triterpenoid saponin with diverse biological activities; selectively inhibits human recombinant renin and porcine kidney renin (IC50s = 30 and 30 μg/ml

Soyasaponin Bb – 10 mg

Brand:
Cayman
CAS:
51330-27-9
Storage:
-20
UN-No:
Non-Hazardous - /

Soyasaponin Bb is a triterpenoid saponin that has been found in soy and has enzyme inhibitory, antimetastatic, anti-inflammatory, and neuroprotective biological activities.{43236,43237,43238,43239,43240,43241} It selectively inhibits human recombinant and porcine kidney renin (IC50s = 30 and 30 μg/ml, respectively) over bovine trypsin, human urinary kallikrein, and rabbit angiotensin converting enzyme (ACE) when used at a concentration of 100 μg/ml.{43237} Soyasaponin Bb inhibits the mouse brain sialyltransferase ST3GAL1 (Ki = 2.1 μM) and decreases levels of α2,3-linked sialic acid on the cell surface and decreases migration of B16/F10 mouse melanoma cells in vitro when used at a concentration of 75 μM.{43238,43239} It also dose-dependently increases viability and mRNA expression of heme oxygenase-1 (HO-1) in BRL 3A immortalized rat hepatocytes subjected to alcohol-induced oxidative stress.{43240} Soyasaponin Bb (10 mg/kg per day) increases the latency to enter the dark chamber in a passive avoidance test and the percentage of spontaneous alterations in the Y-maze test in a rat model of learning and memory impairment induced by ibotenic acid (Item No. 14584).{43241}  

 

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SKU: 25140 - 10 mg Category:

Description

A triterpenoid saponin with diverse biological activities; selectively inhibits human recombinant renin and porcine kidney renin (IC50s = 30 and 30 μg/ml, respectively) over bovine trypsin, human urinary kallikrein, and rabbit ACE at 0.1 μg/ml; inhibits mouse brain ST3GAL1 (Ki = 2.1 μM) and decreases levels of α2,3-linked sialic acid on the cell surface and decreases migration of B16/F10 mouse melanoma cells in vitro at 75 μM; dose-dependently increases viability and mRNA expression in BRL 3A immortalized rat hepatocytes subjected to alcohol-induced oxidative stress; increases the latency to enter the dark chamber in a passive avoidance test and the percentage of spontaneous alterations in the Y-maze test in an ibotenic acid-induced rat model of learning and memory impairment at 10 mg/kg per day

Formal name: (3β,4β,22β)-22,23-dihydroxyolean-12-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-β-D-galactopyranosyl-(1→2)-β-D-glucopyranosiduronic acid

Synonyms:  Soyasaponin I

Molecular weight: 943.1

CAS: 51330-27-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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