Description
A polyketide with diverse biological activities; inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells (GI50s = 7.4-62 nM); is cytostatic against HUVECs (IC50 = 26 nM); inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs; inhibits HIF-1α mRNA splicing and reduces HIF-1α protein levels in HepG2 cells grown under hypoxic conditions at 0.05 μM; inhibits splicing of p27Kip mRNA in HeLa cells; increases LDL receptor promoter-driven transcription in a cell-based reporter assay at 0.1 and 1 μM; has herbicidal activity against wild buckwheat, morning glory, maize, hemp sesbania, and rapeseed at a rate of 0.069 kg/hectare
Formal name: 5,6-anhydro-6-C-[(2S,3E,5E)-6-[(2S,3S,6R)-6-(carboxymethyl)tetrahydro-3-methyl-2H-pyran-2-yl]-2-methyl-3,5-heptadien-1-yl]-1,4,7-trideoxy-4-methyl-3-O-methyl-L-glycero-L-gluco-heptitol
Synonyms: GEX1A|Tan 1609
Molecular weight: 438.6
CAS: 142861-00-5
Purity: ≥70%
Formulation: A solid
Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Polyketides||Product Type|Biochemicals|Pesticides|Herbicides||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer|Angiogenesis||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Toxicology|Environmental|Agriculture
