An amide form of trans-cinnamic acid and a metabolite of Streptomyces; inhibits growth of BEL-7402 human hepatoma cells and HT-1080 fibrosarcoma cells (IC50s = 1.94 and 1.29 mM

Cinnamamide – 5 g

Brand:
Cayman
CAS:
621-79-4
Storage:
-20
UN-No:
Non-Hazardous - /

Cinnamamide is an amide form of of trans-cinnamic acid and a metabolite of Streptomyces.{43048} Cinnamamide exhibits low cytotoxicity against BEL-7402 human hepatoma cells and HT-1080 fibrosarcoma cells and inhibits cell growth (IC50s = 1.94 and 1.29 mM, respectively).{43049} In vivo, cinnamamide (40 and 100 mg/kg, i.p.) reduces tumor weight in a mouse model of C26 murine colon carcinoma. Cinnamamide (75 and 150 mg/kg, i.p.) also reduces tumor weight in a mouse model of murine hepatoma 22 by 42% and 49%, respectively, without reducing body weight when delivered one or three days following tumor implantation. When presented with cinnamamide-treated food at a concentration of 0.8% w/w, house and wood mice food consumption is reduced to 32% and 17% of pretreatment levels, respectively, however, wood mouse consumption returns to pretrial levels by day two.{43050}  

 

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Description

An amide form of trans-cinnamic acid and a metabolite of Streptomyces; inhibits growth of BEL-7402 human hepatoma cells and HT-1080 fibrosarcoma cells (IC50s = 1.94 and 1.29 mM, respectively); reduces tumor weight in a mouse model of C26 murine colon carcinoma at 40 and 100 mg/kg, i.p.; reduces tumor weight in a mouse model of murine hepatoma 22 by 42% and 49% at 75 and 150 mg/kg, i.p., respectively; treated food reduces consumption by house and wood mice to 32% and 17% of pretreatment levels, respectively, at 0.8% w/w

Formal name: 3-phenyl-2-propenamide

Synonyms:  NSC 32953

Molecular weight: 147.2

CAS: 621-79-4

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death||Research Area|Toxicology|Environmental

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