A bacterial metabolite; inhibits growth in the NCI-60 cancer cell line panel (GI50s = 0.1-17 μM) with the RPMI8226 multiple myeloma

Spirohexenolide A – 100 µg

Brand:
Cayman
CAS:
1193347-22-6
Storage:
-20
UN-No:
Non-Hazardous - /

Spirohexenolide A is a metabolite originally isolated from S. platensis.{42121} It inhibits growth in the NCI-60 cancer cell line panel (GI50s = 0.1-17 μM) with the RPMI-8226 multiple myeloma, HOP-92 lung, and SW620 colon cancer cell lines being most sensitive (GI50s = 254, 191, and 565 nM, respectively). Spirohexenolide A also binds to human macrophage migration inhibition factor (MIF; Kd = 35.9 μM) and inhibits MIF cellular uptake and lysosomal localization in HCT116 cells.{42122}  

 

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SKU: 25116 - 100 µg Category:

Description

A bacterial metabolite; inhibits growth in the NCI-60 cancer cell line panel (GI50s = 0.1-17 μM) with the RPMI8226 multiple myeloma, HOP-92 lung, and SW620 colon cancer cell lines being most sensitive (GI50s = 254, 191, and 565 nM, respectively); binds MIF (Kd = 35.9 μM); inhibits MIF cellular uptake and lysosomal localization in HCT116 cells ,

Formal name: (3E,7Z,9R,11E,13E,14aR,17S,18aS)-6,9,10,14a,17,18-hexahydro-9-hydroxy-13,14a,16,17-tetramethyl-4,7-etheno-3,18a-methano-2H,18aH-1,5-benzodioxacyclohexadecin-2,19-dione

Synonyms: 

Molecular weight: 408.5

CAS: 1193347-22-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer

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