An iridoid glycoside with diverse biological activities; attenuates ANIT-induced acute cholestasis and liver damage and reverses bile acid dyshomeostasis in mice at 130 mg/kg; increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice at 25

Gentiopicrin – 25 mg

Brand:
Cayman
CAS:
20831-76-9
Storage:
-20
UN-No:
Non-Hazardous - /

Gentiopicrin is an iridoid glycoside that has been found in G. rigescens and has diverse biological activities.{36986,36987,36988} In vivo, gentiopicrin (130 mg/kg) attenuates acute cholestasis and liver damage and reverses bile acid dyshomeostasis induced by α-napthylisothiocyanate (ANIT) in mice.{36986} It increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice when administered at doses of 25, 50, and 100 mg/kg.{36987} Gentiopicrin (100 mg/kg) also decreases NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in the nucleus accumbens and reverses morphine-induced conditioned place preference in mice.{36988}  

 

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SKU: 25102 - 25 mg Category:

Description

An iridoid glycoside with diverse biological activities; attenuates ANIT-induced acute cholestasis and liver damage and reverses bile acid dyshomeostasis in mice at 130 mg/kg; increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice at 25, 50, and 100 mg/kg; decreases NMDA receptor-mediated EPSCs in the nucleus accumbens and reverses morphine-induced conditioned place preference in mice at 100 mg/kg

Formal name: (5R,6S)-5-ethenyl-6-(β-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one

Synonyms:  Gentiopicroside|NSC 606402

Molecular weight: 356.3

CAS: 20831-76-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Pain Research

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