A ferroptosis inducer; an indirect GPX4 inhibitor and iron oxidizer; decreases GPX4 activity and protein levels in vitro; oxidizes iron in vitro; induces lipid peroxidation of a large subset of the lipidome in HT-1080 cells at 10 µM; induces ferroptosis in an arachidonic acid lipoxygenase-independent manner; inhibits growth of and induces lethality in the NCI-60 panel of cancer cell lines (mean GI50 = 5.8 µM; mean LC50 = 46 µM); selective for oncogenically transformed BJ-ELR cells over noncancerous BJ-hTERT cells at 15 and 20 µM; induces oxidative stress

FINO2 – 1 mg

Brand:
Cayman
CAS:
869298-31-7
Storage:
-20
UN-No:
Non-Hazardous - /

FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron.{35318} It decreases GPX4 activity and protein levels in vitro but does not act as an active site, allosteric, or covalent inhibitor of GPX4 or alter GPX homeostasis. It also oxidizes iron in vitro, leading to degradation of the endoperoxide moiety, but does not affect the protein levels of iron regulatory proteins, such as IRP2, FTL1, or TFR. FINO2 induces lipid peroxidation of a large subset of the lipidome in HT-1080 cells when used at a concentration of 10 µM and induces ferroptosis in an arachidonic acid lipoxygenase-independent manner. It inhibits cell growth (mean GI50 = 5.8 µM) and induces lethality (mean LC50 = 46 µM) in the NCI-60 panel of cancer cell lines.{35102} It is selective for oncogenically transformed BJ-ELR cells over noncancerous BJ-hTERT cells when used at concentrations of 15 and 20 µM. FINO2 (6 µM) induces oxidative stress, including lipid peroxidation, in RS4;11 B-lymphoblastic leukemia cells. It induces iron-dependent cell death, an effect that can be blocked by pretreatment with the lipophilic antioxidants ferrostatin-1 (Item No. 17729) and liproxstatin-1 (Item No. 17730), and does not induce markers of apoptosis, necrosis, or autophagy in RS4;11 cells.  

 

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Description

A ferroptosis inducer; an indirect GPX4 inhibitor and iron oxidizer; decreases GPX4 activity and protein levels in vitro; oxidizes iron in vitro; induces lipid peroxidation of a large subset of the lipidome in HT-1080 cells at 10 µM; induces ferroptosis in an arachidonic acid lipoxygenase-independent manner; inhibits growth of and induces lethality in the NCI-60 panel of cancer cell lines (mean GI50 = 5.8 µM; mean LC50 = 46 µM); selective for oncogenically transformed BJ-ELR cells over noncancerous BJ-hTERT cells at 15 and 20 µM; induces oxidative stress, including lipid peroxidation, in RS4;11 B-lymphoblastic leukemia cells at 6 µM

Formal name: (5α,8α)-8-(1,1-dimethylethyl)-3-methyl-1,2-dioxaspiro[4.5]decane-3-ethanol

Synonyms: 

Molecular weight: 256.4

CAS: 869298-31-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ox Stress Reagents||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase

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