A neutral polyene with antifungal activity; inhibits cell growth as well as mitochondrial terminal electron transport in S. cerevisiae at 135 µg/ml; binds to various sterols in aqueous solutions and fungal cell membranes at 50 µg/ml; induces membrane pit formation and leakage of cell contents; has been used to label sterols within biological structures for imaging; ex/em = 338/480 nm

Filipin Complex – 5 mg

Brand:
Cayman
CAS:
11078-21-0
Storage:
-20
UN-No:
Non-Hazardous - /

Filipin complex is a neutral polyene originally isolated from S. filipinensis with antifungal activity.{42119} It inhibits cell growth as well as mitochondrial terminal electron transport in S. cerevisiae when used at a concentration of 135 µg/ml. Filipin complex binds to various sterols, particularly 24α-methyl cholesterol (Item no. 17344), 24α-ethyl cholesterol (Item no. 11756), and cholesterol, in aqueous solutions and in fungal cell membranes when used at a concentration of 50 µg/ml, inducing membrane pit formation and leakage of cell contents.{42120,9103,42106} It is a fluorescent compound that has been used to label sterols within biological structures for imaging.{9103,8625,42104,42105} Filipin complex displays excitation/emission maxima of 338/480 nm, respectively.  

 

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SKU: 25073 - 5 mg Category:

Description

A neutral polyene with antifungal activity; inhibits cell growth as well as mitochondrial terminal electron transport in S. cerevisiae at 135 µg/ml; binds to various sterols in aqueous solutions and fungal cell membranes at 50 µg/ml; induces membrane pit formation and leakage of cell contents; has been used to label sterols within biological structures for imaging; ex/em = 338/480 nm, respectively

Formal name:

Synonyms:  U-5956

Molecular weight: 654.8

CAS: 11078-21-0

Purity: ≥95%

Formulation: A solid

Application|Fluorescence||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Cell Biology|Mitochondrial Biology

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