A flavonoid; inhibits human recombinant PDE5A1 (IC50 = 0.16 μM) in a cell-free assay; protects PC12 rat adrenal cells from hydrogen peroxide-induced death at 25 μM; inhibits the proliferation of HeLa human cervical

Baohuoside I – 10 mg

Brand:
Cayman
CAS:
113558-15-9
Storage:
-20
UN-No:
Non-Hazardous - /

Baohuoside I is a flavonoid that has been isolated from E. koreanum and has diverse biological activities, including enzyme inhibitory, cytoprotective, neuroprotective, antiproliferative, and erectile function properties.{17617,42242,42243,42244,42245} It inhibits human recombinant phosphodiesterase 5A1 (PDE5A1; IC50 = 0.16 μM) in a cell-free assay and protects PC12 rat adrenal cells from hydrogen peroxide-induced death when used at a concentration of 25 μM.{17617,42242} Baohuoside I inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively).{42244} It decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a rat model of neurodegeneration induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.{42243} Baohuoside I (10 mg/kg per day) also increases intracavernous pressure (ICP) in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction.{42245}  

 

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SKU: 25062 - 10 mg Category:

Description

A flavonoid; inhibits human recombinant PDE5A1 (IC50 = 0.16 μM) in a cell-free assay; protects PC12 rat adrenal cells from hydrogen peroxide-induced death at 25 μM; inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively); decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a STZ-induced rat model of neurodegeneration at 10 mg/kg per day; increases ICP in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction at 10 mg/kg per day,

Formal name: 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

Synonyms:  Icariin II|Icariside II

Molecular weight: 514.5

CAS: 113558-15-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders||Research Area|Neuroscience|Neuroprotection

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