A polyphenol with diverse biological activities; inhibits ACE and α-glucosidase; reduces mutagenicity of Trp-P-1 against S. typhimurium by 59% at 0.57 mM; has antioxidant activity in ferric reducing

3,4-Dicaffeoylquinic Acid – 50 mg

Brand:
Cayman
CAS:
14534-61-3
Storage:
-20
UN-No:
Non-Hazardous - /

3,4-Dicaffeoylquinic acid (3,4-DCQA) is a polyphenol with diverse biological activities.{41896,41897,41898,41899} 3,4-DCQA (1-500 μg/ml) inhibits acetylcholinesterase (ACE) and α-glucosidase in a concentration-dependent manner.{41896,41898} It reduces mutagenicity of Trp-P-1 against S. typhimurium by 59% when used at a concentration of 0.57 mM.{41897} 3,4-DCQA has antioxidant activity in ferric reducing, β-carotene bleaching, and DPPH scavenging assays (EC50s = 2.18, 23.85, and 68.91 μg/ml, respectively).{41898} It is cytotoxic to NCI-H23 lung adenocarcinoma cells (EC50 = 3.26 μg/ml). In vivo, 3,4-DCQA (50 mg/kg) increases tumor necrosis factor-related apoptosis inducing ligand (TRAIL) mRNA, reduces influenza H1N1 hemagglutinin (HA) mRNA, and increases survival in a mouse model of influenza A infection.{41899}  

 

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SKU: 25053 - 50 mg Category:

Description

A polyphenol with diverse biological activities; inhibits ACE and α-glucosidase; reduces mutagenicity of Trp-P-1 against S. typhimurium by 59% at 0.57 mM; has antioxidant activity in ferric reducing, β-carotene bleaching, and DPPH scavenging assays (EC50s = 2.18, 23.85, and 68.91 μg/ml, respectively); cytotoxic to NCI-H23 lung adenocarcinoma cells (EC50 = 3.26 μg/ml); increases TRAIL mRNA, decreases H1N1 HA mRNA, and increases survival in a mouse model of influenza A infection

Formal name: (1S,3R,4R,5R)-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,5-dihydroxy-cyclohexanecarboxylic acid

Synonyms:  3,4-DCQA|Isochlorogenic Acid B

Molecular weight: 516.5

CAS: 14534-61-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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