A diterpene tanshinone with diverse biological activities; inhibits RHL-2H3 mast cell degranulation (IC50 = 14.3 μM); prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM); inhibits the production of TNF mRNA and protein in MCF-7 cells; reduces the viability of MCF-7

15,16-Dihydrotanshinone I – 5 mg

Brand:
Cayman
CAS:
87205-99-0
Storage:
-20
UN-No:
De Minimis - 3077 / 9

15,16-Dihydrotanshinone I (DHTS) is a diterpene tanshinone that has been found in the roots of S. miltiorrhiza with diverse biological activities.{39842} DHTS inhibits RHL-2H3 mast cell degranulation with an IC50 value of 14.3 μM and reduces the tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2) and ERK.{39843} It prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM) and inhibits the production of TNF mRNA and protein in MCF-7 cells.{39842} DHTS reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells with IC50 values of 0.84, 0.92, and 1.2 μM, respectively. It also reduces collagen-induced aggregation of washed rabbit platelets (IC50 = 8.7 μM).{39844} In vivo, DHTS (25 mg/kg per day) reduces tumor growth in an HL-60 leukemia mouse xenograft model by 68% relative to control without decreasing body weight.{39845} In mice with scopolamine-induced learning and memory impairment, DHTS (2-4 mg/kg, p.o.) increases latency to step-through in a passive avoidance test by approximately 3- to 4-fold, and it inhibits acetylcholinesterase in brain homogenate (IC50 = 25 μM).{39846}  

 

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Description

A diterpene tanshinone with diverse biological activities; inhibits RHL-2H3 mast cell degranulation (IC50 = 14.3 μM); prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM); inhibits the production of TNF mRNA and protein in MCF-7 cells; reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells (IC50s = 0.84, 0.92, and 1.2 μM, respectively); reduces collagen-induced aggregation of washed rabbit platelets (IC50 = 8.7 μM); reduces HL-60 leukemia tumor growth in a mouse xenograft model by 68% at 25 mg/kg; increases latency to step-through in a passive avoidance test in mice with scopolamine-induced learning and memory impairment at 2-4 mg/kg, p.o.

Formal name: (1R)-1,2-dihydro-1,6-dimethyl-phenanthro[1,2-b]furan-10,11-dione

Synonyms:  DHTS|Dihydrotanshinone I

Molecular weight: 278.3

CAS: 87205-99-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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