An HIV-1 integrase inhibitor and free radical scavenger; inhibits HIV-1 integrase 3' end processing

1,5-Dicaffeoylquinic Acid – 5 mg

Brand:
Cayman
CAS:
19870-46-3
Storage:
-20
UN-No:
Non-Hazardous - /

1,5-Dicaffeoylquinic acid (1,5-DCQA) has been found in A. montana and is an HIV-1 integrase inhibitor and free radical scavenger.{43193,43194} 1,5-DCQA inhibits HIV-1 integrase 3′ end processing, end joining, and disintegration with IC50 values of 0.35, 0.56, and 0.84 μg/ml, respectively.{43194} It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED50value of 2 μg/ml. 1,5-DCQA (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe (fMLP; Item No. 21495) in a dose-dependent manner.{43193} It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes when used at concentrations ranging from 5 to 100 µM.{43195}  

 

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Description

An HIV-1 integrase inhibitor and free radical scavenger; inhibits HIV-1 integrase 3′ end processing, end joining, and disintegration (IC50s = 0.35, 0.56, and 0.84 μg/ml, respectively); inhibits HIV-1 replication in MT-2 cells (ED50 = 2 μg/ml); dose-dependently reduces the level of free radicals released by FMLP stimulation of PMN cells at 0.25-1 μM; dose-dependently increases cell survival and GSH levels and decreases ROS and LDH release when rat cerebral astrocytes in an oxygen-glucose deprivation/reperfusion assay using rat cerebral astrocytes at 5-100 μM

Formal name: (1S,3R,4R,5R)-1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-cyclohexanecarboxylic acid

Synonyms:  1,3-Dicaffeoylquinic Acid|1,5-DCQA

Molecular weight: 516.5

CAS: 19870-46-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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