An active metabolite of aconitine; inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay; inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells; toxic to mice at 120 mg/kg; induces flaccid paralysis and toxicity in rats (TD50 = 1.5 μmol/animal; LD50 = 1.7 μmol/animal)

Aconine – 1 mg

Brand:
Cayman
CAS:
509-20-6
Storage:
-20
UN-No:
Non-Hazardous - /

Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine.{42252} It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner.{42253} Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells. In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg.{42252} It induces flaccid paralysis and toxicity in rats with toxic dose (TD50) and LD50 values of 1.5 and 1.7 μmol per animal, respectively.{42254}  

 

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SKU: 25048 - 1 mg Category:

Description

An active metabolite of aconitine; inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay; inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells; toxic to mice at 120 mg/kg; induces flaccid paralysis and toxicity in rats (TD50 = 1.5 μmol/animal; LD50 = 1.7 μmol/animal),

Formal name: (1α,3α,6α,14α,15α,16β)-20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-3,8,13,14,15-pentol

Synonyms: 

Molecular weight: 499.6

CAS: 509-20-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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