An internal standard for the quantification of ticagrelor by GC- or LC-MS

Ticagrelor-d7 – 1 mg

Brand:
Cayman
CAS:
1265911-55-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ticagrelor-d7 is intended for use as an internal standard for the quantification of ticagrelor (Item No. 15425) by GC- or LC-MS. Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM; IC50 = 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.{25099,23701} It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.{23699} Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.  

 

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SKU: 25027 - 1 mg Category:

Description

An internal standard for the quantification of ticagrelor by GC- or LC-MS

Formal name: (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propyl-1,1,2,2,3,3,3-d7-thio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol

Synonyms: 

Molecular weight: 529.6

CAS: 1265911-55-4

Purity: ≥99% deuterated forms (d1-d7)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Coronary Artery Disease

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