Description
A triterpenoid saponin with diverse biological activities; reduces expression of TNF-α, IL-6, and IL-1β in LPS-stimulated primary mouse macrophages; increases the survival rate in mice with LPS-induced lethal endotoxemia; reduces weight loss, brain edema, blood-brain barrier disruption, and cortex IL-6 and TNF-α protein levels in the ipsilateral cortex in a rat model of traumatic brain injury at 20 mg/kg; reduces the number of nasal rubs and levels of serum TNF-α in an ovalbumin-sensitized allergic rhinitis mouse model in vivo at 8 mg/kg; reduces duration and frequency of epileptiform discharges in rat hippocampal CA1 neurons in a 4-AP seizure model; decreases viability in six HCC, H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines at 20 µM; prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo at 2 mg/kg
Formal name: (3β,4α,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside
Synonyms:
Molecular weight: 781
CAS: 20736-09-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Infectious Disease|Viral Diseases||Research Area|Neuroscience|Seizure Disorders
