A fungal metabolite; inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM); decreases plasma glucose levels in mice after administration of sucrose (3.1-31.6 mg/kg); decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice (10 mg/kg); antagonist of NK1 receptors (Kis = 12

Benzomalvin A – 1 mg

Brand:
Cayman
CAS:
157047-96-6
Storage:
-20
UN-No:
Non-Hazardous - /

Benzomalvin A is a fungal metabolite produced by Penicillium.{43022,38039} It inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM).{43022} In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P (Item No. 24035) to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 μM, respectively).{38039}  

 

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SKU: 25016 - 1 mg Category:

Description

A fungal metabolite; inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM); decreases plasma glucose levels in mice after administration of sucrose (3.1-31.6 mg/kg); decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice (10 mg/kg); antagonist of NK1 receptors (Kis = 12, 42, and 43 μM for guinea pig, rat, and human receptors, respectively)

Formal name: (6S,7S)-6,7-dihydro-6-methyl-7-(phenylmethyl)-quinazolino[3,2-a][1,4]benzodiazepine-5,13-dione

Synonyms:  (-)-Benzomalvin A

Molecular weight: 381.4

CAS: 157047-96-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience

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