Verbascoside – 1 mg

Brand:
Cayman
CAS:
61276-17-3
Storage:
-20
UN-No:
Non-Hazardous - /

Verbascoside is a natural phenylpropanoid glucoside that has been found in a variety of plants, including B. cordata, B. officinalis, and S. vulgaris, and has diverse biological activities.{42167,42168,42171,42169,42170} Verbascoside is a PKC inhibitor (IC50 = 25 μM).{42168} It inhibits the growth of Gram-positive and Gram-negative bacteria with MIC values ranging from 4 to 128 μg/ml including S. aureus and E. coli (MICs = 16 and 32 μg/ml, respectively).{42171} Verbascoside (0.1-10 μg/ml) dose-dependently reduces extracellular hydrogen peroxide concentrations and increases cell viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+) administration to induce apoptosis and oxidative stress.{42167} It also inhibits the growth of MGC803 human gastric adenocarcinoma cells in a dose-dependent manner when used at concentrations ranging from 10 to 20 μM with maximal growth inhibition of 53%.{42169} In a rat model of colitis induced by 2,4-dinitrobenzene sulfonic acid (DNBS), verbascoside (0.2-2 mg/kg) reduces colon damage and the expression of TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS).{42170}  

 

Available on backorder

SKU: 24965 - 1 mg Category:

Description

A natural phenylpropanoid glucoside; inhibits PKC (IC50 = 25 μM); inhibits the growth of Gram-positive and Gram-negative bacteria, including S. aureus and E. coli (MICs = 16 and 32 μg/ml, respectively); dose-dependently reduces extracellular hydrogen peroxide and increases cell viability of PC12 cells at 0.1-10 μg/ml following MPP+ administration to induce apoptosis and oxidative stress; dose-dependently inhibits the growth of MGC803 adenocarcinoma cells at 10-20 μM; reduces colon damage and the expression of TNF-α, IL-1β, and iNOS in a rat model of DNBS-induced colitis at 0.2-2 mg/kg,


Formal name: 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

Synonyms:  Acteoside|NSC 603831

Molecular weight: 624.6

CAS: 61276-17-3

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer||Research Area|Immunology & Inflammation|Gastric Disease|Crohn’s Disease||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen