A polyphenol with diverse biological activities; inhibits histamine release from anti-EA IgE antibody-sensitized rat peritoneal mast cells from 0.1 to 1 mg/ml; reduces proliferation of MDA-MB-231 breast cancer cells (IC50 = 22 μg/ml) and HUVECs; inhibits human placental aromatase activity (IC50 = 15 μM); lytic against T. cruzi amastigotes (MBC50 = 0.12 pM); decreases RAW 264.7 osteoclastogenesis at 20 μM

(−)-Gallocatechin Gallate – 1 mg

Brand:
Cayman
CAS:
4233-96-9
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-Gallocatechin gallate ((–)-GCG) is a catechin polyphenol that has been found in oolong tea stems and green tea extracts with diverse biological activities.{37587,41815,37588,41816,37589} It inhibits histamine release from anti-egg albumin (EA) IgE antibody-sensitized rat peritoneal mast cells when used at concentrations ranging from 0.1 to 1 mg/ml.{37587} (–)-GCG reduces proliferation of MDA-MB-231 breast cancer cells (IC50 = 22 μg/ml) and human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner.{41815} It also inhibits human placental aromatase activity (IC50 = 15 μM).{37588} (–)-GCG is lytic against T. cruzi amastigotes, with a 50% bactericidal concentration (MBC50) value of 0.12 pM.{41816} It also decreases RAW 264.7 osteoclastogenesis when used at a concentration of 20 μM.{37589}  

 

Available on backorder

Add to quotes
SKU: 24962 - 1 mg Category:

Description

A polyphenol with diverse biological activities; inhibits histamine release from anti-EA IgE antibody-sensitized rat peritoneal mast cells from 0.1 to 1 mg/ml; reduces proliferation of MDA-MB-231 breast cancer cells (IC50 = 22 μg/ml) and HUVECs; inhibits human placental aromatase activity (IC50 = 15 μM); lytic against T. cruzi amastigotes (MBC50 = 0.12 pM); decreases RAW 264.7 osteoclastogenesis at 20 μM

Formal name: 3,4,5-trihydroxy-benzoic acid, (2S,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

Synonyms:  (–)-GCG|NVP-XAA225

Molecular weight: 458.4

CAS: 4233-96-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Polyphenols||Research Area|Cancer|Angiogenesis||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Chagas Disease

Related products

  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 10 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 50 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 500 µg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 500 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 100 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page