A bacterial metabolite that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density; induces neurite outgrowth and branching of chick cortical neurons in vitro (16 and 32 µM); enhances axon sprouting following spinal cord injury and in uninjured serotonin spinal cord neurons

Cyclo(L-Phe-L-Val) – 5 mg

Brand:
Cayman
CAS:
35590-86-4
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclo(L-Phe-L-Val) is a metabolite of the sponge bacterium Pseudoalteromonas sp. NJ6-3-1 that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density.{39700} It induces neurite outgrowth and branching of chick cortical neurons in vitro when used at concentrations of 16 and 32 µM.{39701} It increases phosphorylation of the PI3K substrate Akt, and neurite outgrowth induced by cyclo(L-Phe-L-Val) can be blocked by the PI3K inhibitor LY294002 (Item No. 70920). Cyclo(L-Phe-L-Val) enhances axon sprouting of calcitonin gene-related protein positive (CGRP+) primary afferents in the spinal cord following crush injury and of serotonin neurons in uninjured spinal cord. Cyclo(L-Phe-L-Val) is also a bitter taste component of cocoa and roasted coffee.{39702}  

 

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SKU: 24943 - 5 mg Category:

Description

A bacterial metabolite that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density; induces neurite outgrowth and branching of chick cortical neurons in vitro (16 and 32 µM); enhances axon sprouting following spinal cord injury and in uninjured serotonin spinal cord neurons

Formal name: 3S-(1-methylethyl)-6S-(phenylmethyl)-2,5-piperazinedione

Synonyms:  DKP101516

Molecular weight: 246.3

CAS: 35590-86-4

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Quorum Sensing||Research Area|Neuroscience

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