A diketopiperazine metabolite; active against various bacteria (MICs = 125-1000 µg/ml) and fungi (MICs = 8-64 µg/ml); inhibits hydroxy radical production (IC50 = 1.8 µM); a bitter tastant that can rapidly permeate rat taste cell membranes (1 mM); a melatonin receptor agonist

Cyclo(L-Leu-L-Trp) – 5 mg

Brand:
Cayman
CAS:
15136-34-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite originally isolated from Penicillium.{39706} It is active against various bacteria (MICs = 125-1000 µg/ml) and fungi (MICs = 8-64 µg/ml), and it inhibits the production rate of hydroxy radicals in an electron spin resonance (ESR) spectroscopy-based assay (IC50 = 1.8 µM).{39707,39708} Cyclo(L-Leu-L-Trp) is a bitter tastant that can rapidly permeate rat taste cell membranes ex vivo when used at a concentration of 1 mM.{39709} It also acts as a melatonin receptor agonist in X. laevis melanophores, inhibiting cAMP accumulation when used at a concentration of 20 µM, an effect that is blocked by the melatonin receptor antagonist luzindole (Item No. 15998).{39710}  

 

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SKU: 24942 - 5 mg Category:

Description

A diketopiperazine metabolite; active against various bacteria (MICs = 125-1000 µg/ml) and fungi (MICs = 8-64 µg/ml); inhibits hydroxy radical production (IC50 = 1.8 µM); a bitter tastant that can rapidly permeate rat taste cell membranes (1 mM); a melatonin receptor agonist, inhibiting cAMP accumulation (20 µM)

Formal name: 3S-(1H-indol-3-ylmethyl)-6S-(2-methylpropyl)-2,5-piperazinedione

Synonyms: 

Molecular weight: 299.4

CAS: 15136-34-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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