A diketopiperazine metabolite; active against VRE strains of E. faecalis including K-99-34

Cyclo(L-Leu-L-Pro) – 25 mg

Brand:
Cayman
CAS:
2873-36-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces.{39703} It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 µg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221.{39703} It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 µg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.{39704}  

 

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SKU: 24941 - 25 mg Category:

Description

A diketopiperazine metabolite; active against VRE strains of E. faecalis including K-99-34, K-00-184, and K-00-221 (MICs = 12.5 µg/ml); inhibits growth of K562, HL-60, and U937 leukemia cells (1-100 µg/ml); has antifouling activity, inhibiting attachment of B. amphitrite larva (EC50 = 0.15 mM)

Formal name: (3S,8aS)-hexahydro-3-(2-methylpropyl)-pyrrolo[1,2-a]pyrazine-1,4-dione

Synonyms:  Maculosin 6

Molecular weight: 210.3

CAS: 2873-36-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Pesticides||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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