A coumarin derivative; prevents LPS-induced increases in IL-1β and TNF-α at 25-100 µM and IL-6 at 25-100 µM; inhibits potassium chloride-induced contraction of isolated rabbit trachea by 50 and 100% at 4.8 and 30 µM

(+)-Praeruptorin A – 25 mg

Brand:
Cayman
CAS:
73069-27-9
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-Praeruptorin A is a coumarin derivative originally isolated from P. praeruptorum.{36657} It prevents LPS-induced increases in IL-1β and TNF-α in a concentration-dependent manner when used at concentrations ranging from 6.25 to 100 µM and IL-6 at concentrations ranging from 25 to 100 µM.{36658} It inhibits potassium chloride-induced contraction of isolated rabbit trachea by 50 and 100% when used at concentrations of 4.8 and 30 µM, respectively.{36659} Topical administration of (+)-praeruptorin A (0.3 µmol/cm2) reduces edema by 22% in a croton oil mouse model of inflammation.{36660}  

 

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SKU: 24915 - 25 mg Category:

Description

A coumarin derivative; prevents LPS-induced increases in IL-1β and TNF-α at 25-100 µM and IL-6 at 25-100 µM; inhibits potassium chloride-induced contraction of isolated rabbit trachea by 50 and 100% at 4.8 and 30 µM, respectively; reduces edema in a croton oil mouse model of inflammation at 0.3 µmol/cm2 applied topically

Formal name: (2Z)-2-methyl-2-butenoic acid, (9S,10S)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b’]dipyran-9-yl ester

Synonyms: 

Molecular weight: 386.4

CAS: 73069-27-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Research Area|Immunology & Inflammation

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