Description
A sesquiterpene; inhibits LPS-induced release of NO, PGE2, TNF-α, and IL-6 from RAW264.7 macrophages at 50 µM; induces apoptosis and cell-cycle arrest, as well as increases caspase-3, caspase-9, and PARP cleavage in A549 human lung carcinoma cells at 100 µM; inhibits glutamate-induced apoptosis and DNA fragmentation in primary embryonic mouse cerebral cortical neurons at 40 µM; inhibits induced angiogenesis in an MDA-MB-231 human breast cancer mouse xenograft model at 25 mg/kg per day; decreases the latency to find the platform in the Morris water maze in a rat model of high-dose homocysteine-induced learning deficits at 0.6 mg/kg per day
Formal name: (4aS,8aR,9aS)-4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-naphtho[2,3-b]furan-2(4H)-one
Synonyms: Atractylenolide β|Codonolactone
Molecular weight: 248.3
CAS: 73030-71-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience
